首都师范大学学报（自然科学版）2013，Vol.34Issue(1)：41-46,6.
力生长因子与成骨细胞
Mechano Growth Factor and Osteoblasts
摘要
Abstract
Bone has potential adaptive capacity to different mechanical stimulation. The growth, development and adaption of bone were regulated by mechanical factors and nonmechanial factors, but the correlative regulation was poorly understood. IGF is a growth factor which is tightly related with mechanical stimulation in skeletalmuscle system. Pre-mRNA of IGF-Ⅰ can be alternatively spiliced into mechano-growth factor under mechanical stimulation conditions. MGF could activate satellite cells, promote the proliferation of osteoblast and inhibit their terminal differentiation. Primary studies show that MGF mainly localize in the nuclear and IGF-IR did not mediate the action of MGF. Till now, the receptor, target and mechanism of MGF signaling is not very clear. In present, we summaried the relationship between MGF and mechanical regulaiton of bone.关键词
力学刺激/胰岛素样生长因子IGF-I/力生长因子MGF/成骨细胞/增殖分化Key words
mechanical stimulation/IGF-Ⅰ/MGF/osteoblast/proliferation and differentiation分类
生物科学引用本文复制引用
宋文静,戴钟铨,吴峰,徐洪杰,胡文祥,李莹辉..力生长因子与成骨细胞[J].首都师范大学学报（自然科学版）,2013,34(1):41-46,6.基金项目
航天医学基础与应用国家重点实验室基金资助项目.项目批准号:SMFA09A08. （）
