山西医科大学学报2012，Vol.43Issue(12)：889-892,4.DOI:10.3969/J.ISSN.1007-6611.2012.12.001
丙泊酚与东莨菪碱合用对大鼠认知功能的影响
Effect of propofol and scopolamine on cognitive function in rats
赵戈 1张朝旭 1李宏峰 1任倩倩 1白玲1
作者信息
摘要
Abstract
Objective To explore the effect of propofol combined with scopolamine on cognitive function in rats. Methods Fifty-six SD rats weighing 230 - 250 g were randomly divided into 4 groups: control group( saline, n = 14 ), propofol group (100 mg/kg, n = 14 ), scopolamine group ( 0. 8 mg/kg,n = 14 ) and propofol + scopolamine group ( 100 mg/kg +0. 8 mg/kg,n = 14 ). The duration of loss and recovery of righting reflex was observed. Eight rats in each group underwent Morris water maze( MWM ) test for 5 consecutive days and the other 6 rats performed step-down test from 12 h after the injection of propofol. MWM test and step-down test were conducted to evaluate the effects of propofol on learning and memory function in terms of escape latency and numbers of error. Results There was no significant difference in the duration of loss and recovery of righting reflex between propofol group and propofol + scopolamine group. In MWM test, compared with control group, the spatial learning at day 1-4 and memory of rats at day 5 was impaired in scopolamine group ( P ＜ 0. 05 - 0.01 ). The mean escape latency was significantly larger at day 1 - 2( P ＜ 0. 01 ) and no difference in the mean escape latency at day 3-4 and the swimming time percentage in platform quadrant at day 5 was found in propofol group( P＞0. 05 ). Compared with scopolamine group, memory disorders increased at day 1 - 2 in propofol + scopolamine group ( P ＜ 0.05 ), and there was no significant difference in learning and memory function test at day 3 - 5 ( P ＞ 0.05 ). In step-down test, as compared to that in control group, the latencies were shortened at day l-2(P＜0.0l) and the numbers of error were increased ( P ＜ 0. 05 -0.01 ) in propofol group and scopolamine group,and they had the same trend at day 3 -4 in scopolamine group ( P ＜0. 05 ) but not in propofol group. Compared to scopolamine group, the latency was decreased at day l(P＜0.0l) and the numbers of error were increased at day 1 -2 in propofol + scopolamine group ( P ＜ 0.05 ), however, there was no significant difference at day 3- 4(P＞0. 05). Conclusion Propofol and scopolamine used alone can both lead to the rat memory disorders. Propofol can aggravate transiently the cognitive dysfunction induced by scopolamine in rats.关键词
丙泊酚/认知功能/东莨菪碱Key words
propofol/ cognitive function/ scopolamine分类
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赵戈,张朝旭,李宏峰,任倩倩,白玲..丙泊酚与东莨菪碱合用对大鼠认知功能的影响[J].山西医科大学学报,2012,43(12):889-892,4.
