山西医科大学学报2012，Vol.43Issue(12)：896-899,973,5.DOI:10.3969/J.ISSN.1007-6611.2012.12.003
抑郁症首次发作患者视觉空间认知的功能偏侧化研究
Hemispheric dominance on visuo-spatial cognitive function in patients with first-episode depression
摘要
Abstract
Objective To explore the functional laterality between left and right hemisphere on visuo-spatial cognitive function in first-episode depressive disorder patients. Methods A total of 35 depressive disorder patients ( experiment group ) and 36 normal healthy subjects ( control group ) were tested to make visuo-spatial rotation tasks by the event-related potential system, and the change of the brain distribution topographic map was observed. Results ①Compared with control group,the mean error rate [ ( 22. 3 ±6. 5 )% vs ( 18. 4 ± 5. 6 )% ] and the mean response time [ ( 761. 4 ± 94. 2 )ms vs ( 634.7 ± 84. 9 )ms ] significantly increased in depressive disorder group ( P ＜0. 05 ). ②Compared with control group,the normal P500 volatility at P4 was significantly decreased in depressive disorder group [ ( 7. 63 ±2. 63 )μV vs ( 9. 58 ±3. 22 )μV,P ＜0. 05 ],and the mirror P500 volatility at P4 was significantly increased[ ( 6. 90 ± 1. 92 )ΜV VS ( 4. 95 ± 1. 92 )μV ,P ＜ 0. 05 ]. In P500, the self mirror-normal difference of excitability disappeared in depressive disorder group. The normal excitability in the right parietal-occipital lobe was significantly higher than that in the left parietal-occipital lobe ( P ＜0. 05 ),but the mirror excitement difference disappeared in depressive disorder group ( P ＞0. 05 ). The normal and mirror excitement in the right parietal-occipital lobe were both significantly higher than those in the left in control group ( P ＜0. 05 ). Conclusion The visuo-spatial cognitive function is impaired in patients with first-episode depression for both normal oriented images and mirror images. The functional laterality is found in normal images for visuo-spatial rotation,but not in mirror images. Specific topographic characteristics of EEG during visuo-spatial rotation tasks are potential biomarkers for first-episode depressive disorder.关键词
首发/抑郁症/空间认知/功能偏侧化/事件相关电位/脑地形图Key words
first-episode/ depressive disorder/ spatial cognition/ functional laterality/ event-related potentials/ brain topographic map分类
医药卫生引用本文复制引用
陈玖,杨来启,李亚萍,刘光雄,吴银霞,王大刚,贾婷..抑郁症首次发作患者视觉空间认知的功能偏侧化研究[J].山西医科大学学报,2012,43(12):896-899,973,5.基金项目
军队中医药科研专项基金资助项目(10ZYX108) （10ZYX108）
2012兰州军区医药卫生科研计划项目(CLZ12JB23) （CLZ12JB23）
