山西医科大学学报2012，Vol.43Issue(12)：949-952,4.DOI:10.3969/J.ISSN.1007-6611.2012.12.020
喘息性婴幼儿外周血嗜酸性粒细胞Caspase-3、Bcl-2的表达及意义
Expression and significance of Caspase-3 and Bcl-2 in peripheral blood eosinophils of infants with wheezing
摘要
Abstract
Objective To investigate the expression of Caspase-3 and Bcl-2 in peripheral blood eosinophils of infants with wheezing, and to explore the roles of Caspase-3 and Bcl-2 in the apoptosis of eosinophils. Methods A total of 120 infants with wheezing were enrolled and divided into three groups based on the age: ≤1 year group( n = 45 ), 1 - 2 years group( n = 35 ),2 -3 years group( n = 40 ). Thirty healthy infants were chosen as controls aged from four months to three years old. Three samples of 4 ml blood were extracted from vein of each infant were used to count the eosinophils and measure the expression of Caspase-3 and Bcl-2 in eosinophils. Results Compared to controls,numbers of eosinophils were increased significantly in infants with wheezing( P ＜0. 05 ),and the activity of Caspase-3 in eosinophils decreased significantly( P ＜0. 05 ) ,and the expression of Bcl-2 increased significantly( P ＜0. 05 ). Conclusion The decrease of Caspase-3 activity and the increase of Bcl-2 expression in peripheral blood eosinophils of infants with wheezing may induce the decrease of apoptosis in peripheral blood eosinophils.关键词
喘息/嗜酸性粒细胞/细胞凋亡/Caspase-3/Bcl-2Key words
wheezing/ eosinophils/ apoptosis/ Caspase-3/ Bcl-2分类
医药卫生引用本文复制引用
卢先锋,杨晓丽,刘晋婷..喘息性婴幼儿外周血嗜酸性粒细胞Caspase-3、Bcl-2的表达及意义[J].山西医科大学学报,2012,43(12):949-952,4.基金项目
山西省人民医院科研基金资助项目(200962) （200962）
