山西医科大学学报2012，Vol.43Issue(12)：958-961,4.DOI:10.3969/J.ISSN.1007-6611.2012.12.023
丙泊酚静脉麻醉3种输注方式在无痛拔牙术中清醒镇静的效果和安全性比较
Efficacy and safety of three modes of intravenous propofol in pain-free tooth extraction
高燕凤 1霍雄伟 1赵亮 1景桂霞 1吕毅1
作者信息
摘要
Abstract
Objective To compare the efficacy and safety of three modes of intravenous propofol in patients undergoing conscious sedation and pain-free tooth extraction. Methods Eighty outpatients with tooth extraction were randomly divided into experimental group and control group. The experimental group was sub-divided into target controlled infusion group, minipump group and manual group according to three different modes of intravenous propofol. Routine local anesthesia was used in control group. Heart rate( HR ), mean arterial pressure( MAP ) and pulse oxygen saturation( SpO2 )were recorded during operation. The depth of controlled sedation,the time of induction and recovery, and the induction dosage and total dosage of propofol were recorded in experimental group. Results In control group,HR and MAP fluctuated greatly during operation and were statistically different from those in pre-operation and post-operation ( P＜0. 05 ). Compared with control group, HR and MAP were also statistically different from the other three groups during operation ( P ＜0. 05 ). HR and MAP in manual group and minipump group,and MAP in target controlled group all decreased significantly 1 min after infusion ( P ＜ 0. 05 ). The Ramsay scale in target controlled group was lower than those in manual group and minipump group ( P ＜0. 05 ). The time of induction and recovery and the total dosage in target controlled group were statistically lower than those in manual group and minipump group( P＜0.01 -0. 05). There was no significant difference in induction dosage among three experiment groups ( P ＜ 0.05 ). There was no significant difference in SpO2 among four groups in operation. Conclusion The hemodynamics of local anesthesia combined with propofol is significantly better than the routine local anesthesia alone. The target controlled infusion of propofol is a safer and more effective anesthesia way for pain-free tooth extraction than minipump and manual infusion.关键词
丙泊酚/清醒镇静/无痛拔牙/靶控输注Key words
propofol/ conscious sedation/ pain-free tooth extraction/ target controlled infusion分类
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高燕凤,霍雄伟,赵亮,景桂霞,吕毅..丙泊酚静脉麻醉3种输注方式在无痛拔牙术中清醒镇静的效果和安全性比较[J].山西医科大学学报,2012,43(12):958-961,4.
