实用妇产科杂志2013，Vol.29Issue(1)：49-52,4.
CXCL12-CXCR4趋化因子轴与卵巢癌关系研究
Potential Value of Chemokine CXCL12-CXCR4 in the Growth of Ovarian Cancer Cells
摘要
Abstract
Objective:To investigate the potential value of chemokine CXCL12-CXCR4 in the growth of o-varian cancer cells. Methods:SKOV3 cells transfected with CRCX4 vector or plasmid,as well as untransfect-ed SKOV3 cells,were cultured in vitro,and assigned into 4 groups (A,B,C,and D)cell proliferation was measured using MTT Assay. Results :①ln SKOV3/CXCR4 group,the cell proliferation in A and B groups is higher than that in C and D groups(P<0. 05) ;And the cell proliferation in B group is higher than A group (P<0. 05) ;②ln SKOV3/CXCR4 group,the number and weight of metastatic tumors in experimental group are lower than those in control group. The live time of nude mice is longer than that in control group ( P < 0.05);③ In SKOV3/neg and SKOV3 group, no significantly differences of the experimental data are observed. Conclusions;Chemokine CXCL12-CXCR4 mightimprove the growth of ovarian cancer cells. The CX-CR4 antibody and antagonist AMD3100 might inhibit the growth of ovarian cancer cells.关键词
卵巢癌/CXCL12/CXCR4/CXCR4拮抗剂/细胞增值Key words
Ovarian cancer/ Stromoal cell-de-rived factor-12/ C-X-C chemokine receptor4/ C-X-C chemokine receptor4 antagonists/Cell proliferation分类
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郭清,吴小华,吕英璞,杨波..CXCL12-CXCR4趋化因子轴与卵巢癌关系研究[J].实用妇产科杂志,2013,29(1):49-52,4.
