实用医学杂志2012，Vol.28Issue(15)：2588-2590,3.DOI:10.3969/j.issn.1006-5725.2012.15.047
阿折地平与氨氯地平对高血压病患者动脉僵硬度与动态脉压的影响
Effects of azelnidipine and amlodipine on artery stiffness and dynamic pulse pressure in patients with essential hypertension
摘要
Abstract
Objective To investigate the impacts of azelnidipine and mlodipine on artery stiffness and dynamic pulse pressure in patients with essential hypertension. Methods Seventy-six hypertensive patients were enrolled into the azelnidipine group and the amlodipine group in this randomized double-blind study. Each patient was given azelnidipine (8 mg) or amlodipine (5 mg) orally everyday for 12 weeks after placebo treatment. The biochemical items, the automatic blood pressure monitor (ABPM) and the brachial ankle pulse wave velocity (baPWV) were determined before and after drug treatment, respectively. Results (1) The seat pressure, ABPM paremnents, baPWV and APP decreased in two groups after 12- week treatment, respectively. (2) No significant differences for the ABPM paremnents, baPWV and APP were shown in two groups. Conclusion Azelnidipine and amlodipine can both markedly decrease baPWV and APP in patients with essential hypertension with no significant difference.关键词
氨氯地平/阿折地平/动脉僵硬度/动态脉压Key words
Amlodipine/ Azelnidipine/Pulse wave velocity/ Dynamic pulse pressure引用本文复制引用
黄荣杰,郑云香,何美霖..阿折地平与氨氯地平对高血压病患者动脉僵硬度与动态脉压的影响[J].实用医学杂志,2012,28(15):2588-2590,3.基金项目
广西壮族自治区卫生厅自筹经费科研课题(编号:桂卫Z2010340) （编号:桂卫Z2010340）
