实用医学杂志2013，Vol.29Issue(2)：202-204,3.DOI:10.3969/j.issn.1006-5725.2013.02.015
老年2型糖尿病患者血糖变异性与糖尿病肾病的关系
Association of glycemic variability and severity of diabetic nephropathy in elderly patients with type 2 diabetes
摘要
Abstract
Objective To investigate association of glycemic variability and severity of diabetic nephropathy in elderly patients with type 2 diabetes. Methods One hundred and fourteen elderly patients with type 2 diabetes were enrolled and divided into 3 groups according to 24 h urinary albumin excretion rate. The 3 groups are as follows: the diabetes group (DM, n = 36), the early diabetic nephropathy group (EDN, n = 44) and the clinical diabetic nephropathy group (DN, n = 34). Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBG), hemoglobin Alc(HbAlc), serum creatinine (Scr), serum cystatin C (Cys C) were determined, and blood glucose level was monitored with continuous glucose monitor system (CGMS). The standard deviation of mean blood glucose (SDBG), the mean amplitude of glycemic excursions (MAGE), the largest amplitude of glycemic excursions (LAGE), the area under curve (AUC) and the absolute means of daily differences (MODD) were also calculated. Results SBP, DBP, HbA1c, sCr and Cys C of DN group were significantly increased than those in the EDN and in the DM groups (P < 0.05), Cys C in the EDN group was significantly higher than that in the DM group (P < 0.05), levels of the SDBG, MAGE, LAGE, AUC and MODD were significantly higher in the DN group than those in the EDN and in the DM groups (P < 0.05), every index of CGMS in the EDN group increased significantly compared with that in the DM group (P < 0.05). Conclusions Glycemic variability has a close relationship with the presence, development and severity of DN in elderly patients with type 2 diabetes.关键词
血糖变异性/糖尿病肾病/2型糖尿病Key words
Glycemic variability/ Diabetic nephropathy/ Type 2 diabetes mellitus引用本文复制引用
张艳,余维巍,姚济华,李彩萍,张存泰,余学锋..老年2型糖尿病患者血糖变异性与糖尿病肾病的关系[J].实用医学杂志,2013,29(2):202-204,3.基金项目
湖北省自然科学基金资助项日(编号:2011CDB548) （编号:2011CDB548）
