西安交通大学学报（医学版）2013，Vol.34Issue(2)：205-209,5.
人肝细胞肝癌中STAT3的表达及其临床意义
Significance of STAT3 expressions in human hepatocellular carcinoma
摘要
Abstract
Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3) in human hepatocellular carcinoma ( HCC ) and its significance in liver cancer. Methods Immunohistochemistry method of SP was employed to detect the expression of STAT3 in 76 HCC tissue specimens; 29 normal hepatic tissue specimens served as controls. The expression of cyclooxygenase-2 (COX-2) was detected at the same time for comparison. Results The positive expression rate of STAT3 in HCC was 68.4% (P<0.05), which was significantly related to the history of alcohol use, tumor diameter, vein invasion and TNM stages ( Ⅰ and Ⅱ ) (P<0.05). The expression of STAT3 in HCC had a positive correlation with COX-2 protein level (r = 0.683, P<0. 05). Conclusion STAT3 and COX-2 are overexpressed in HCC and may be involved in early hepatocarcinogenesis. STAT3/COX-2 related signal pathway may play an important role at the early stage of HCC.关键词
环氧合酶2/信号传导与激活因子3/肝细胞肝癌/临床病理指标Key words
cyclooxygenase-2 (COX-2)/ signal transducer and activator of transcription 3 (STAT3)/ hepatocellular carcinoma/ clinicopathological indicator分类
医药卫生引用本文复制引用
司望利,宋瑛,胡雅楠,任牡丹,张雅欣,和水祥..人肝细胞肝癌中STAT3的表达及其临床意义[J].西安交通大学学报（医学版）,2013,34(2):205-209,5.基金项目
国家自然科学基金面上项目(No.30771895) （No.30771895）
