西安交通大学学报（医学版）2013，Vol.34Issue(2)：233-236,4.
血管内皮祖细胞与VEGF对增生性糖尿病视网膜病变新生血管形成的影响
Effects of endothelial progenitor cells and VEGF on neovascularization in proliferative diabetic retinopathy
摘要
Abstract
Objective To investigate the effects as well as the interaction between endothelial progenitor cells (EPCs) and vascular endothelial growth factor (VEGF) on the occurrence and development of proliferative diabetic retinopathy (PDR) by detecting the fibrovascular membranes in PDR patients. Methods We collected 10 PDR membranes stripped from vitreous surgery; 10 PVR membranes and 1 human retina served as controls. Morphology of the membranes was observed. VEGF expression and EPCs counting were observed by immunohistochemistry. Results PDR membranes consisted of the central avascular area, the middle fiber structure with a few cells, and the peripheral rich cell area. Cells were distributed disorderly in PVR membranes. EPCs were found in all the 10 PDR membranes (5.90±1.83) and in only 1 PVR membrane (0. 10±0. 32), but not in human retina. VEGF expression in PDR membranes was significantly higher than in the control group (P<0.001). The number of EPCs was positively correlated with VEGF expression in PDR membranes. Conclusion EPCs and VEGF participate in and have a synergistic effect on neovascularization in PDR.关键词
增生性糖尿病视网膜病变/血管内皮祖细胞/血管内皮生长因子/新生血管形成Key words
proliferative diabetic retinopathy ( PDR)/ endothelial progenitor cells ( EPCs)/ vascular endothelial growth factor (VEGF)/ neovascularization分类
医药卫生引用本文复制引用
谢安明,王雅君,崔丽珺..血管内皮祖细胞与VEGF对增生性糖尿病视网膜病变新生血管形成的影响[J].西安交通大学学报（医学版）,2013,34(2):233-236,4.
