西安交通大学学报（医学版）2013，Vol.34Issue(2)：244-247,269,5.
椒蒿对自身免疫性睾丸炎小鼠CD4+CD25+调节性T细胞的影响
Effects of pepper artemisia on CD4+CD25+ regulatory T cells in experimental autoimmune orchitis mice
摘要
Abstract
Objective To study the effects of volatile oil from pepper artemisia leaves on CD4+ CD25+ regulatory T cells in murine autoimmune orchitis mice. Methods Totally 80 male BALB/c mice were randomly divided into 4 groups (normal saline group, model group, olive oil group, and pepper artemisia group). After model making, each group received gavage three days before the surgery, and for 24 days after the surgery (saline group received only the gavage, but no operation). CD4+CD25 + regulatory T cells in the peripheral blood were detected by flow cytometry 3 and 9 weeks after the surgery. Results Three weeks after the surgery, the percentage of peripheral blood CD4+ CD25+ regulatory T cells in model group, olive oil group and pepper artemisia group was significantly lower than that in saline group (P<0.05), but the differences among the first three groups were not significant (P>0.05). Nine weeks after the operation, the percentage of peripheral blood CD4+CD25+ regulatory T cells was significantly lower in model group and olive oil group than in saline group (P<0.05); however, pepper artemisia group and saline group did not differ significantly (P>0.05). Conclusion Pepper artemisia can increase the percentage of CD4+CD25+ regulatory T cells, which exert immunity-regulatory effects on autoimmune orchitis mice.关键词
椒蒿/自身免疫性睾丸炎/CD4+CD25+调节性T细胞/BALB/c小鼠Key words
pepper artemisia/ autoimmune orchitis/ CD4+CD25+ regulatory T cell/ BALB/c mouse分类
医药卫生引用本文复制引用
仵燕,斯依提尼沙汗·吾满尔,吴小川,骆靖华,玛衣拉·阿不拉克..椒蒿对自身免疫性睾丸炎小鼠CD4+CD25+调节性T细胞的影响[J].西安交通大学学报（医学版）,2013,34(2):244-247,269,5.基金项目
国家自然科学基金资助项目(No.30660054) （No.30660054）
