医药导报2013，Vol.32Issue(2)：142-145,4.DOI:10.3870/yydb.2013.02.003
O-羧甲基壳聚糖抑菌作用研究
Study on Antibacterial Activity of O-carboxymethyl Chitosan
摘要
Abstract
Objective To investigate antibarterial activity of self-synthesized O-earboxymethyl chitosan ( O-CMC ) . Methods Antibacterial rates were calculated by colony counting. Effects of different positions of the raboxymethyl group, different concentrations and pH of O-CMC on antibacterial activity were compared. Results The antimicrobial test demonstrated that the antibacterial activities of O-CMC were better than those of N, O-CMC or N-CMC. The antibacterial activities of O-CMC increased with concentration and decreased with pH over a ceitain range. It was also found that O-CMC showed stronger antibacterial activities against gram-positive bacteria than against gram-negative bacteria. Conclusion The synthesized O-CMC possesses a broad-spectrum antibacterial property.关键词
O-羧甲基壳聚糖/抑菌作用Key words
O-carboxymethyl chitosan/Antibacterial activity分类
医药卫生引用本文复制引用
吴迪,刘辉,浦金辉,张婧,邹萍,郭旦峰..O-羧甲基壳聚糖抑菌作用研究[J].医药导报,2013,32(2):142-145,4.基金项目
武汉市科技攻关计划(200960323135) （200960323135）
全军医学科研"十二五"计划课题(CWS11C274) （CWS11C274）
