医药导报2013，Vol.32Issue(2)：159-162,4.DOI:10.3870/yydb.2013.02.008
香桂化浊胶囊毒理学研究
Toxicologic Studies on Xianggui Huazhuo Capsules
摘要
Abstract
Objective To investigate possible acute and chronic toxicities of xianggui huazhuo capsules for clinical reference. Methods Maximal tolerated dose (MTD) was established in mice for acute toxicity evaluation. In the chronic toxicological study, rats were treated with intragastrical gavage (i. g) administration for 12 weeks, and then two thirds of the the animals were sacrificed and the others were kept for observation in recovery phase for additional 2 weeks. Activity, body weights, excretion, food-intake, and external appearance of the treated animals were observed and recorded. Haematological and blood biochemical parameters were detected, and pathological examinations performed. Results No evident toxicity was observed in mouse acute toxicity test. The MTD was 48 g · kg-1 , equivalent to 480 times of the clinically recommended dose (0. 1 g · kg-1 ). No severe toxicity was found in high, middle, or low dose group in the long-term evaluation. No organic changes were observed in pathological tests. Conclusion Xianggui huazhuo capsules is safe for i. g. administration in rats at the recommended clinical dose.关键词
香桂化浊胶囊/毒性,急性/毒性,长期Key words
Xianggui huazhuo capsules/Toxicity, acute /Toxicity, chronic分类
医药卫生引用本文复制引用
刘红淼,李艳玲,杨继章,姜少灏..香桂化浊胶囊毒理学研究[J].医药导报,2013,32(2):159-162,4.基金项目
河北省中医药管理局科研计划课题资助项目(2012083) （2012083）
