中国临床药理学与治疗学2013，Vol.18Issue(2)：186-189,4.
右美托咪啶复合丙泊酚靶控输注对喉罩置入条件的影响
Laryngeal mask insertion conditions at different target plasma concentrations of propofol combined with dexmedetomidine
摘要
Abstract
AIM: To compare the laryngeal mask insertion conditions at different plasma target concentrations (Cp) during the induction of anesthesia with target-controlled infusion (TCI) of propofol combined with dexmedetomi dine.METHODS: Seventy-five ASA Ⅰ-Ⅱ pa tients of both sexes aged 20-60 years, weighing 50-80 kg, in which the use of laryngeal mask was indicated were randomly divided into 3 groups (n=25) according to Cp of propofol set during induction of anesthesia: 2.0, 2.5 and 3.0 μg/mL.Dexmedetomidine 0.6 μg/kg was in fused over 10 minitues.Then,TCI propofol was given by Diprifusor ( Graseby 3500 infusion pump).Laryngeal mask was inserted when the effect-site concentration ( Ce ) of propofol reached the settled Cp.Laryngeal mask insertion conditions (jaw mobility, coughing, head and limb movement, laryngeal spasm) were as sessed.SBP, MAP, HR and BIS value were re corded at four time points: baseline before induc tion (To), instant before laryngeal mask insert ed (T1 ), 1 min (T2) and 3 min (T3) after inser tion of laryngeal mask.Changes of SBP, MAP and HR between T1 and T0 were calculated.The number of patients with apnea and apnea times were recorded.The administration of atropine and ephedrine was also recorded.RESULTS:The levels of SBP, MAP and HR were decreased with increasing depth of anesthesia in the 3 groups.The decline rates of SBP, MAP and HR after induction had significantly differences in group III than those in group I and II (P < 0.05).BIS value was similar in all groups.The insertion conditions were significantly better in group II and III than that in group I.More pa tients developed apnoea and their apnoea times were longer in group III than the other two groups (P<0.05).More patients were adminis trated with atropine and ephedrine in group III compared with the other two groups (P<0.05).CONCLUSION: Induction of anesthesia with dexmedetomidine 0.6 jug/kg combined with TCI of propofol with Cp set at 2.5 μg/mL is satisfac tory for laryngeal mask insertion in terms of car diovascular stability and insertion conditions.关键词
丙泊酚/右美托咪定/靶控输注/喉罩Key words
Propofol/Dexmedetomidine/Target-controlled infusion/Laryngeal masks分类
医药卫生引用本文复制引用
仲俊峰,胡双燕,李玉红,陈念平..右美托咪啶复合丙泊酚靶控输注对喉罩置入条件的影响[J].中国临床药理学与治疗学,2013,18(2):186-189,4.基金项目
浙江省医学会临床科研基金(2011ZYC-A88) （2011ZYC-A88）
