中国临床药理学与治疗学2013，Vol.18Issue(2)：190-194,5.
慢性丙型肝炎患者血清IL-21水平检测及临床意义
Serum IL-21 levels in patients with chronic hepatitis C and clinical significance of IL-21
摘要
Abstract
AIM: To determine serum inter leukin-21 (IL-21) level and evaluate the roles of IL-21 in chronic hepatitis C (CHC).METHODS: Serum IL-21 levels of 27 CHC patients and 10 control subjects were determined by enz ymelinked immunosorbent assay (ELISA) and the relationship between serum IL-21 levels and HCV-RNA, the live biochemical parameters were studied.RESULTS: Serum IL-21 levels in CHC patients were significantly higher than those in control subjects (P<0.01).Especially, CHC patients with elevated alanine aminotrans-ferase (ALT) have higher IL-21 than patients with normal ALT.There were highly significant positive associations between serum IL-21 and ALT (r=0.647, P<0.01) as well as aspartate aminotransferase (AST) (r=0.591, P<0.01).But no association was observed between IL-21 and HCV-RNA.CONCLUSION: IL-21 is a cyto-kine involved in HCV-associated liver pathologi cal damage and may be an available marker to e-valuate hepatic inflammation for CHC.关键词
白细胞介素21/病毒性肝炎,丙型,慢性/炎症Key words
IL-21/Chronic hepatitis C/Inflammation分类
医药卫生引用本文复制引用
潘庆春,余永胜,汤正好,奚敏,臧国庆..慢性丙型肝炎患者血清IL-21水平检测及临床意义[J].中国临床药理学与治疗学,2013,18(2):190-194,5.基金项目
国家自然科学基金(81077335) （81077335）
上海市自然科学基金(08ZR1411500) （08ZR1411500）
