中国临床药理学与治疗学2013，Vol.18Issue(2)：194-197,4.
阿奇霉素对支气管哮喘患者肺功能及血清结缔组织生长因子的影响
Effects of azithromycin on lung function and serum CTGF of asthma patients
郑美梅 1王方剑 1岳铁刚 1董丽妍 1段成城1
作者信息
摘要
Abstract
AIM: To observe the clinical effi cacy of azithromycin on bronchial asthma, and the effects on lung function, serum connective tissue growth factor (CTGF).METHODS: 48 cases of asthma were randomly divided into con ventional treatment group (group A), azithro mycin in treatment group (group B).Two groups were inhaled budesonide, group B was given azithromycin additional, 18 healthy people were distributed to control group (group C).The level of serum CTGF was detected by en zyme-linked immunosorbent assay (ELISA).The changes of asthma control test ( ACT ) scores,lung function, serum CTGF were evalua ted in each group patients before and after treat ment.RESULTS: After 8 weeks treatment, the levels of ACT scores, lung function were significantly improved than before treatment, but the serum CTGF concentrations were decreased in group A and B(all P<0.05).After 8 weeks treatment,compared with group A, the levels of ACT scores,lung function were significantly in creased in group B, but the CTGF serum con centration was decreased ( all P<0.05).CON CLUSION: Azithromycin can inhibit airway re modeling, improve lung function and control asthma, the reason may be related to inhibiting the expression of CTGF.关键词
阿奇霉素/支气管哮喘/肺功能/结缔组织生长因子/气道重塑Key words
Azithromycin/Asthma/Lung function/Connective tissue growth factor/Airway remodeling分类
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郑美梅,王方剑,岳铁刚,董丽妍,段成城..阿奇霉素对支气管哮喘患者肺功能及血清结缔组织生长因子的影响[J].中国临床药理学与治疗学,2013,18(2):194-197,4.
