中国免疫学杂志2013，Vol.29Issue(2)：135-139,5.DOI:10.3969/j.issn.1000-484X.2013.02.005
甘肃产藏药五脉绿绒蒿有效部位对肝纤维化疗效和TGF-β1表达的影响
Influence of active fractions of MQR growing in Gansu Province on effect and expression of TGF-β1 of experimental liver fibrosis in rat
摘要
Abstract
Objective: To investigate the influence of active fractions of Meconopsis quintuplinervia Regel( MQR) growing in Gansu Province on TGF-β1 of experimental liver fibrosis in rats. Methods:Under drug's effects, using sc CC14, eating high-fat low-protein diet and drinking 20% alcohol in six weeks, the model of hepatic fibrosis rats was established to valuate the effects of the extractive parts from MQR through detecting indexes in serum and hepatic tissue and expression of TGF-β1. Results;The extractive of ethanol, total flavones and mixture of total flavones and total alkaloids from MQR growing in Gansu Province could significantly decrease ALT, AST and TGF-β1 in serum and Hyp and collagen protein in hepatic tissue, and they could also inhibit the expression of TGF-β1 in the liver tissue of the rats. The effects of total flavones exhibit the dose-effect relationship. Conclusion: The ethanol extractive from MQR growing in Gansu Province and total flavones in it have better protecting effects on hepatic fibrosis in rats induced by carbon tetrachloride compounded other factors, and the one of mechanisms maybe that it can inhibit the expression of TGF-β1 in hepatic fibrosis tissue.关键词
肝纤维化/四氯化碳/五脉绿绒蒿/总黄酮/转化生长因子β1Key words
Hepatic fibrosis/ Carbon tetrachloride/ Meconopsis quintuplinervia Regel/ The total flavones/ TGF-β1分类
医药卫生引用本文复制引用
王志旺,程小丽,郭玫,王瑞琼,邵晶,任远..甘肃产藏药五脉绿绒蒿有效部位对肝纤维化疗效和TGF-β1表达的影响[J].中国免疫学杂志,2013,29(2):135-139,5.基金项目
本文为甘肃省中医药英才基金资助项目(No.GZK-2010-52)、甘肃省中医药管理局基金资助项目(No.GZK-2008-31) （No.GZK-2010-52）
