中国免疫学杂志2013，Vol.29Issue(2)：154-157,4.DOI:10.3969/j.issn.1000-484X.2013.02.009
可溶性Fas表达水平与人黑色素瘤相关性的初步研究
Expression of soluble Fas is correlated to human malignant melanoma
摘要
Abstract
Objective: To investigate the apoptosis related mechanisms of Fas/Fas ligand and soluble Fas in malignant mela-nomaby by analyze soluble Fas(sFas) expression in primary human malignant melanoma. Methods: Analyze the pathological and disease staging records by reviewing 35 cases of human malignant melanoma, determine Fas/FasL expression by immunoflourescence. Analyze soluble Fas expression levels in serum samples of patients by ELJSA. Results;In 35 cases of malignant melanoma, there were 2 cases of superficial spreading melanoma, 9 cases of nodular melanoma, 18 cases of acral letiginous melanoma and 6 cases of lentigo maligna melanoma. Fas expression was high in normal skin tissues and low in malignant melanomas, when FasL expression was the opposite. The soluble Fas levels showed significant differences in malignant melanoma, compare to melanocytic nevus and normal people were (36.32 ±11.57) ng/ml,(7.33 ±3.78) ng/ml and (4.18 ± 1. 88) ng/ml respectively. Conclusion:Soluble Fas was highly expressed in malignant melanoma, which is correlated to the malignancy. Soluble Fas may competitively play important roles in apoptosis mechanisms of malignant melanoma.关键词
细胞凋亡/黑色素细胞瘤/可溶性Fas/Fas/Fas配体Key words
Apoptosis/ Malignant melanoma/ Soluble Fas/ Fas/Fas ligand分类
医药卫生引用本文复制引用
谭岩,王永晨,白晓,芦小单,方艳秋..可溶性Fas表达水平与人黑色素瘤相关性的初步研究[J].中国免疫学杂志,2013,29(2):154-157,4.基金项目
本文受吉林省科技厅基础研究项目(201015216)、吉林省科技厅重点实验室项目(20122113)、吉林省科技厅科技创新项目(20082102)、黑龙江省卫生厅资助课题(2007-247)资助 （201015216）
