中国普通外科杂志2013，Vol.22Issue(2)：170-173,4.DOI:10.7659/j.issn.1005-6947.2013.02.009
脂氧酶12编码区遗传变异与胃癌发病的关系
Relationship between genetic variation in encoding region of 12-lipoxygenase gene and risk of stomach cancer
摘要
Abstract
Objective: To investigate the association of Arg261 Gin polymorphism in the coding region of 12-lipoxygenase (LOX12) gene with the risk of developing stomach cancer. Methods: The LOX12 genotypes in 148 patients with gastric cancer and 148 cancer-free controls were determined by using PCR-restriction fragment length polymorphism (PCR-RFLP). The association between the genotypes and risk of developing gastric cancer was estimated by logistic regression model. Results: The allele frequency for L0X12 Arg261Gln in gastric cancer patients (0.544) was higher than that of the normal controls (0.443). Compared with the Arg/Arg genotype carriers, the risk of developing gastric cancer was increased in Gln/Gln genotype carriers (OR=2.26, 95%CI=1.15-4.46, P=0.018), while those with the heterozygous genotype Arg/Gln showed no increased risk of developing gastric cancer (OR=1.37, 95%CI=0.77-2.44; P=0.284). Conclusion: The inherited polymorphisms of Arg261Gln in LOX12 gene encoding region may confer genetic susceptibility to development of stomach cancer.关键词
胃肿瘤/遗传学/多态性,单核苷酸/花生四烯酸盐12-脂氧合酶Key words
Stomach Neoplasms/genet/Polymorphism, Single Nudeotide/Arachidonate 12-Lipoxygenase分类
医药卫生引用本文复制引用
戴亮,曹立瀛..脂氧酶12编码区遗传变异与胃癌发病的关系[J].中国普通外科杂志,2013,22(2):170-173,4.基金项目
河北省卫生厅科技计划资助项目(20090624). （20090624）
