中国全科医学2013，Vol.16Issue(8)：853-856,4.DOI:10.3969/j.issn.1007-9572.2013.03.043
盐酸多奈哌齐治疗老年痴呆的疗效研究
Clinical Efficacy of Donepezil in the Treatment of Senile Dementia
摘要
Abstract
Objective To evaluate the clinical efficacy of Donepezil in the treatment of senile dementia. Methods A total of 106 senile dementia patients admitted to our hospital were randomly divided into treatment group ( n = 53 ) and control group ( n =53 ). The two groups were both given primary treatment, and the treatment group was given additional Donepezil treatment. Clinical symptoms, physical signs, MMSE score and ADL score were compared between the two groups before treatment, three months and two years after treatment. Results Among the 106 senile dementia patients, 44 cases were male ( 41. 5% ) and 62 cases were female ( 58. 5% ); the patients were aged from 60 to 90, and 82 cases were from 60 to 75 ( 77. 3% ) and 24 cases were from 76 to 90 ( 22.7% ); 73 cases were under college degree ( 68. 87% ) and 33 cases were college degree or above ( 31. 13% ); 72 cases had Alzheimer's disease ( AD ) ( 67. 9% ), 23 cases had vascular dementia ( VaD ) ( 21. 7% ) and 11 cases had other dementia ( 10. 4% ). 92 cases were followed up and 14 cases lost following up during the two - year follow up. The MMSE score and ADL score before treatment and on three - month following up between the two groups showed no statistically significant difference ( P > 0. 05 ), but showed statistically significant differences on two - year following up ( P <0. 05 ). Both groups had adverse effects and were improved after symptomatic treatment. The incidence of adverse effect between the two groups showed no statistically significant difference ( x2 = 1- 38, P > 0. 05 ). Conclusion Donepezil is safe and effective treatment for senile dementia with little adverse reaction. Donepezil may be regarded as one of best treatments for senile dementia.关键词
痴呆/阿尔茨海默病/痴呆,血管性/随访研究Key words
Dementia/ Alzheimer disease/ Dementia, vascular/ Follow - up studies分类
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杨红,朱德生..盐酸多奈哌齐治疗老年痴呆的疗效研究[J].中国全科医学,2013,16(8):853-856,4.
