中国全科医学2013，Vol.16Issue(8)：884-887,4.DOI:10.3969/j.issn.1007-9572.2013.03.053
转化生长因子β1基因-509C/T多态性与原发性肾病综合征相关关系的研究
Association of TGFβ1-509C/T Polymorphism with Primary Nephrotic Syndrome
项新 1黄典胜 1施燕春 1梁延秀 1黄振华 1何坤 1陆玲娜1
作者信息
摘要
Abstract
Objective To investigate the association of TGFpU - 509C/T polymorphism with primary nephrotic syndrome ( PNS ). Methods The genotypes of TGFpl gene polymorphism ( - 509C/T ) was determined by polymerase chain reaction - restriction fragment - length polymorphism analysis in 80 PNS patients and 60 normal controls. The clinical and pathological data were also obtained and compared between these two groups. Results TGFβ1 gene ( -509C/T) included three genotype ( CC, CT, and TT ) and two allele gene ( C or T ) in both two groups. The genotype distribution and allele frequency were not significantly different between these two groups ( P >0. 05 ). In the PNS group, the serum creatinine and 24 h urine protein were significantly higher in patients with TT genotype than those with CT genotype or CC genotype ( P < 0. 05 ), whereas the age, sex, blood pressure, and albumine showed no significant differnce ( P>0. 05 ). The frequency of TT genotype was significantly higher than that of CC + CT in patients with mesangial proliferative glomerulonephritis ( P <0. 05 ). Both TT genotype and T allele were associated with significantly lower effectiveness rate ( P <0. 05 ). Conclusion TGFβ1 - 509C/T Polymorphism may be associated with severe renal tissue lesion, albuminuria, and mesangial proliferative glomerulonephritis. Patients with TT genotype and T allele tend to have poor prognosis. However, this polymorphism is not associated with the susceptibility to PNS.关键词
转化生长因子β1/肾病综合征/多态性,单核苷酸/相关性Key words
Transforming growth factor beta 1/ Nephrotic syndrome/ Polymorphism, single nuceotide / Relationship分类
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项新,黄典胜,施燕春,梁延秀,黄振华,何坤,陆玲娜..转化生长因子β1基因-509C/T多态性与原发性肾病综合征相关关系的研究[J].中国全科医学,2013,16(8):884-887,4.
