中国全科医学2013，Vol.16Issue(9)：974-976,3.DOI:10.3969/j.issn.1007-9572.2013.03.080
重组人脑利钠肽对急性心肌梗死泵功能衰竭患者心肌重构的影响分析
Influence of Recombinant Human Brain Natriuretic Peptide on Cardiac Remodeling in Patients with Myocardial Infarction with Pump Failure
摘要
Abstract
Objective To explore the influence of recombinant human brain natriuretic peptide ( BNP ) on myocardial remodeling in patients with acute myocardial infarction ( AMI ) with pump failure. Methods 118 AMI patients with pump failure admitted to our hospital from May 2009 to April 2010 were randomly divided into control group and experiment group. The control group was given routine treatment, while the experiment group was given recombinant human BNP in addition to routine treatment. Cardiac ultrasound examination was conducted before treatment and one year after treatment Serum BNP, norepinephrine ( NE ), endothelin - 1 ( ET - 1 ), antidiuretic hormone ( ADH ) and creatinine ( Cr ) were detected before treatment and after two weeks treatment. Results The clinical efficacy and major adverse cardiac events ( MACE ) between the two groups showed statistically significant differences ( P < 0. 05 ) . Before treatment, the LVEF, LVEDD and LAD between the two groups showed no statistically significant difference ( P > 0. 05 ), but one year after treatment the above mentioned indicators all showed statistically significant differences ( P < 0. 05 ) . After two weeks treatment, the levels of BNP, NE and ET - 1 in experiment group were significantly lower than the control group ( P < 0. 05 ) . Conclusion The recombinant human brain natriuretic peptide have good inhibitory effect on cardiac remodeling in patients with myocardial infarction with pump failure, and can improve patients' cardiac hemodynamic function as well as patients' prognosis.关键词
利钠肽,脑/心肌梗死/心室重构Key words
Natriuretic peptide, brain/ Myocardial infarction/ Ventricular remodeling分类
医药卫生引用本文复制引用
徐峰,杨学成,程璐,卢云凤,王冲..重组人脑利钠肽对急性心肌梗死泵功能衰竭患者心肌重构的影响分析[J].中国全科医学,2013,16(9):974-976,3.基金项目
辽宁省教育厅(L2010692) （L2010692）
