中国全科医学2013，Vol.16Issue(9)：987-990,4.DOI:10.3969/j.issn.1007-9572.2013.03.084
血清Fractalkine和超敏C反应蛋白与早期2型糖尿病肾病的相关性研究
Relationship of Serum Fractalkine and High Sensitivity C-Reactive Protein with Early Type 2 Diabetic Nephropathy
摘要
Abstract
Objective To investigate serum fractalkine ( FKN ) and high sensitivity C - reactive protein ( hs - CRP ) levels in normoalbuminuria and microalbuminuria period of type 2 diabetes and analyze the association of fractalkine and hs - CRP with urinary microalbumin excretion. Methods According to urinary albumin - to - creatinine ratio ( UACR ), a total of 139 patients with type 2 diabetes in endocrinology department of Jiangsu province hospital of Traditional Chinese Medicine between March 2009 and February 2010 were divided into normoalbuminuria group ( UACR <30 mg/g, 92 cases ) and microalbuminuria group ( 30 mg/g ≤ UACR < 300 mg/g, 47 cases ) . The basic characteristics of all subjects ( including sex, age, courses, etc ) were collected. UACR and blood chemistries were determined. FKN and hs - CRP were measured by enzyme - linked immunosorbent assay ( ELISA ) and immune turbidimetry respectively. The blood biochemical indices, FKN and hs - CRP levels of the two groups were compared. The relationship of FKN and hs - CRP levels with biochemical indices were analysed using Pearson correlation and multiple stepwise regression methods. Results ( 1 ) Differences of FBG, HbA1c and hs - CRP level between the two groups were statistically significant ( P <0. 01 ), while blood lipids, FKN levels and eGFR had no significant differences ( P >0. 05 ) . ( 2 ) FKN was positively correlated with body mass index ( BMI ), waist circumference, serum triglyceride and hs - CRP level ( P <0. 05 ) . The level of hs - CRP was positively related to BMI, waist circumference, eGFR, serum triglyceride and UACR ( P <0. 01 ) and negatively related to HDL - C level ( P <0. 05 ). (3) Multiple stepwise linear regression analysis showed that BMI was independently associated with FKN (β = 0. 32, P < 0. 01, R2 = 0. 40 ); While BMI (β = 0. 30, P < 0. 01, R2 = 0. 37 ) and UACR ((3 = 0. 17, P < 0. 01, R2 = 0. 27 ) had independent positive correlation with hs - CRP. Conclusion FKN level is not significantly associated with UACR and metabolic index of patients in T2DM. While hs - CRP level is positively correlated with early diabetic nephropathy.关键词
Fractalkine/超敏C反应蛋白/糖尿病,2型/糖尿病肾病/尿微量清蛋白/肌酐Key words
Fractalkine/ High sensitivity C - reactive protein/ Diabetes mellitus, type 2/ Diabetic nephropathies/Urinary albumin - to - creatinine ratio分类
医药卫生引用本文复制引用
谢绍锋,黄莉吉,赵越,安晓飞,刘敬顺,余江毅..血清Fractalkine和超敏C反应蛋白与早期2型糖尿病肾病的相关性研究[J].中国全科医学,2013,16(9):987-990,4.基金项目
国家"十一五"科技支撑计划重大项目(2006BAI04A03-1) （2006BAI04A03-1）
