中国全科医学2013，Vol.16Issue(9)：991-994,4.DOI:10.3969/j.issn.1007-9572.2013.03.085
2型糖尿病患者血清基质金属蛋白酶2和金属蛋白酶2组织抑制剂及超敏C反应蛋白与大血管病变的关系研究
Discussion of the Association between Serum MMP-2,TIMP-2 and hs-CRP and Macroangiopathy of Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the association between the levels of serum MMP - 2, TIMP - 2, hs - CRP and macroangiopathy of patients with type 2 diabetes mellitus ( T2DM ) . Methods According to CIMT, 60 T2DM patients admitted to our department from September 2010 to April 2011 were divided into CIMT non - thickening group ( CIMT≤0. 9 mm ) and CIMT thickening group ( CIMT >0. 9 mm ) with each group 30 cases. 30 healthy people who underwent physical examination in our hospital were involved as control group. ELISA method was used to detect the serum MMP - 2 and TIMP - 2, and automatic biochemical analyzer was used to detect the serum hs - CRP in the three groups. The three indicators were compared among the three groups, and Pearson correlation analysis and multiple linear regression analysis were conducted for the three indicators, clinical and biochemical indicators. Results ( 1 ) Among the three groups, serum MMP - 2 [ ( 547 ± 130 ), ( 986 ± 104 ) and ( 1 346±204) μg/L], TIMP-2 [ (67.3 ±9.4), ( 87. 2 ± 6. 5 ) and ( 102. 6 ± 14. 5 ) μg/L ] and hs - CRP [ (0.92 ±0. 28 ), ( 2. 72 ± 1. 12 ) and ( 4. 29 ± 2. 59 ) mg/L ] showed statistically significant differences ( P < 0. 01 ), and pairwise comparison also showed statistically significant differences ( P < 0. 05 ). (2) Correlation analysis showed that serum MMP - 2, TIMP - 2 and hs - CRP were all positively correlated with systolic pressure, TC, LDL - C and HbA,c ( P < 0. 05 ), but were negatively correlated with HDL - C ( P < 0. 01 ) . Besides, serum MMP - 2 was positively correlated with TG, FPG, TIMP - 2 and hs - CRP ( P < 0. 05 ), serum TIMP - 2 was positively correlated with diastolic pressure, TG and hs - CRP ( P < 0. 05 ), hs - CRP was positively correlated with FPG ( P <0. 01 ) . Regression analysis showed that TIMP -2 and hs - CRP were the major factors influencing the MMP - 2 ( standardized regression coefficient was 0. 829 and 0. 166 respectively, Pboth, < 0. 05 ) . MMP - 2 and diastolic pressure were the major factors influencing the TIMP - 2 ( standardized regression coefficient was 0. 904 and 0. 147 respectively, Pboth, < 0. 05 ) . MMP - 2 and systolic pressure were the major factors influencing the hs - CRP ( standardized regression coefficient was 0. 488 and 0. 317 respectively, Pboth <0. 05 ) . Conclusion The levels of serum MMP - 2, TIMP -2 and hs - CRP in T2DM patients, especially those combined with macroangiopathy, were significantly higher than healthy people. MMP - 2 and TIMP - 2 may be closely related to inflammation. The detection of serum MMP - 2, TIMP - 2 and hs - CRP is of great significance for the surveillance of the occurrence and development of macroangiopathy in T2DM.关键词
基质金属蛋白酶2/金属蛋白酶2组织抑制剂/超敏C反应蛋白/糖尿病,2型/糖尿病血管病变Key words
Matrix metalloproteinase 2/ Tissue inhibitor of metalloproteinase - 2/ Hypersensitive C - reactive protein / Diabetes mellitus, type 2/ Diabetic angiopathies分类
医药卫生引用本文复制引用
唐灵,涂晶晶,陈春莲,彭昱..2型糖尿病患者血清基质金属蛋白酶2和金属蛋白酶2组织抑制剂及超敏C反应蛋白与大血管病变的关系研究[J].中国全科医学,2013,16(9):991-994,4.基金项目
广西科学研究与技术开发计划项目(桂科攻11138007) （桂科攻11138007）
