中国全科医学2013，Vol.16Issue(9)：1050-1052,3.DOI:10.3969/j.issn.1007-9572.2013.03.104
吸附无细胞百白破联合疫苗疑似预防接种异常反应监测分析
Analysis on Adverse Events Following Immunization Surveillance of DTaP
兰蓓 1张东彦 1王中战 1张建军 1赵建忠1
作者信息
摘要
Abstract
Objective To analyze the occurrence features of adverse events following immunization ( AEFI ) surveillance of absorbed diphtheria, tetanus and acellular pertusis combined vaccine ( DTaP ) in Fengtai District of Beijing and to evaluate the immunization safety of DTaP and the running condition of AEFI surveillance system. Methods AEFI data of Fengtai District of Beijing from 2008 to 2011 were collected through AEFI Information System and China immunization information system and epide-miological analysis was conducted by using descriptive methods. Results Totally 61 DTaP AEFI cases were reported from 2008 to 2011 in Fengtai District of Beijing by the surveillance system. The report incidence rate of AEFI was 13. 88/100 000 doses and most of AEFI were reported during May to August. The DTaP AEFI incidence of 2008 ,2009,2010 and 2011 showed statistically significant differences (x2 = 17. 312, P =0.001 ),and the incidence in 2011 was much higher than 2009 (x2 = 11.018,P = 0. 001 ). The DTaP AEFI incidence of different dose showed statistically significant difference (x2 =95. 586,P =0. 000 ). The 4th dose incidence was significantly higher than the first,second and thrid dose (X2 =38. 604,39. 805 ,35. 105 ,P =0. 000 ). Among all AEFI reported,50 cases was common minor reaction (11. 38/100 000 doses ) with fever ( ≥38. 6 ℃ ) and ( or ) local swelling ( >2. 5 cm) and ( or) local induration;9 cases was rare serious reaction ( 2. 05/100 000 doses ) with anaphylactic rash;2 cases were coupling diseases ( 0. 46/100 000 doses ). Conclusion DTaP has good immunization safety. The AEFI surveillance system runs well in Fengtai District and can provided scientific basis for vaccine safety.关键词
白喉-破伤风-百日咳菌苗/接种/预防接种异常反应Key words
Diphtheria - tetanus - pertussis vaccine/ Vaccination/ Adverse events following immunization分类
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兰蓓,张东彦,王中战,张建军,赵建忠..吸附无细胞百白破联合疫苗疑似预防接种异常反应监测分析[J].中国全科医学,2013,16(9):1050-1052,3.
