癌变·畸变·突变2013，Vol.25Issue(2)：96-99,4.DOI:10.3969/j.issn.1004-616x.2013.02.004
大豆黄素对有机氯类农药诱导乳腺癌细胞增殖效应的抑制作用
Inhibitory action of the daidzein on organochlorine pesticideinduced MCF-7 breast cancer cell multiplication
摘要
Abstract
OBJECTIVE: To investigate the combined action of inhibitory daidzein and organochlorine pesticides on MCF-7 cell multiplication. METHODS：MCF-7 human breast carcinoma cells in logarithmic growth phase were exposed to each of daidzein，chlordane，β-HCH，o，p'-DDT in different concentration alone and another group with 100 μmol/L daidzein combined with each pesticide. A solvent control group (0.1% DMSO) was set up. After 48 h of incubation，the cell multiplication was assessed by MTT. RESULTS：Compared with solvent group，the 100 μmol/L daidzein only group reduced cell multiplication. All different concentrations of each organochlorine pesticide could increase cell multiplication (P<0.05). Compared with the single agent treatment group，the rate of cell multiplication in combined treatment group was significantly reduced (P<0.05). CONCLUSION：Daidzein could inhibit cell multiplication induced by different concentrations of o rganochlorine pesticides.关键词
大豆黄素/有机氯农药/细胞增殖/乳腺癌细胞Key words
daidzein/organochlorine pesticide/cell m ultiplication/breast cancer cells分类
医药卫生引用本文复制引用
张明,那晓琳,杨洋,易成..大豆黄素对有机氯类农药诱导乳腺癌细胞增殖效应的抑制作用[J].癌变·畸变·突变,2013,25(2):96-99,4.基金项目
国家自然科学基金项目(30972439) （30972439）
