癌变·畸变·突变2013，Vol.25Issue(2)：127-133,7.DOI:10.3969/j.issn.1004-616x.2013.02.011
线粒体DNA中D-loop区突变在非小细胞肺癌中的意义
The significance of mitochondrial DNA D-loop region mutations in non-small cell lung cancer
摘要
Abstract
OBJECTIVE: To study the role of mitochondrial DNA (mtDNA) mutations in D-loop region in non-small cell lung cancer patient's and its possible clinical application. METHODS：The mtDNA of both cancer and paracancerous tissue cells of 20 non-small cell lung cancer patients was extracted， the D-loop region propagated by PCR sequenced，and mutations taking the mtDNA D-loop sequences of the human genome as control were analyzed. RESULTS：Mutations were found in the sequence of the cancer and paracancerous tissue cells of all 20 cases of nonsmall cell lung cancers. Among the 265 mutations there were 69 specific mutations of cancer tissue，96 specific mutations of paracancerous tissue and 50 common mutations. CONCLUSION：The mutations of D-loop region of mtDNA occurred mainly in HVRII region，and it may play an important role in the development of non-small cell lung cancer. 关键词
线粒体DNA/D-loop区/突变/肺癌Key words
mtDNA/D-loop region/mutation/lung cancer分类
生物科学引用本文复制引用
江磊,王祖义,汪国文,赵华..线粒体DNA中D-loop区突变在非小细胞肺癌中的意义[J].癌变·畸变·突变,2013,25(2):127-133,7.
