重庆医学2013，Vol.42Issue(10)：1092-1094,3.DOI:10.3969/j.issn.1671-8348.2013.10.005
ω-3鱼油脂肪乳注射液治疗重症急性胰腺炎的临床疗效研究
The effects of ω-3 fish oil fat emulsion Injection on patients with severe acute pancreatitis
摘要
Abstract
Objective To investigate the effects of ω-3 fish oil fat emulsion injection on patients with severe acute pancreatitis (SAP) and explore its working mechanism. Methods A total of 64 SAP patients were collected in this study. All the 64 cases were divided into two groups: control group(n=32) and ω-3 fish oil fat emulsion injection treatment group(n = 32). The clinic effects were compared between each group. The sub-distribution of T cells were detected by flow cytometry analysis. The serum level of IL-1β and TNF-α was determined by ELISA analysis. Results The mortality rate in control group was 28. 1% and it was 9. 4% higher than that of treatment group(P<0. 05). The complication rate of control group was 34. 4% ,and it was 15. 6% higher than that of treatment group(P<0. 05). The recovery time of bowel function and hospital duration were both better in treatment group than that of control group(P<0. 05). Compared with healthy people,the proportions of CD4 positive lymphocytes of people in the control group and treatment group were significantly lower on the first and third day after treatment(P<0. 05). The proportion of CD4 positive cells of people in the control group were still lower than healthy people on the fifth day after the treatment(P>0. 05) while it returned to normal in the treatment group(P>0. 05). The expression levels of IL-1β and TNF-α of SAP patients were significantly higher than healthy people (P<0. 05);while compared with the first day after the treatment,the expression levels of IL-lfi and TNF-a of the control group began to decrease from the fifth day after treatment (P<0. 01) and in the treatment group it began to decrease from the third day after treatment (P<0. 01). The decrease of the expression levels of IL-1β and TNF-α of the treatment group were significantly better than control group (P<0. 01). Conclusion ω-3 fish oil fat emulsion injection could treat SAP effectively. The up regulation of CD4 positive cells and downregulation of IL- 1β and TNF-α are the main mechanism.关键词
重症急性胰腺炎/ω-3鱼油脂肪乳/免疫功能/炎症反应Key words
severe acute pancreatitis/ω-3 fish oil fat emulsion injection/immune function/inflammation引用本文复制引用
唐碧波,胡东辉..ω-3鱼油脂肪乳注射液治疗重症急性胰腺炎的临床疗效研究[J].重庆医学,2013,42(10):1092-1094,3.基金项目
湖北省科技攻关计划资助项目(2010AA302B08). （2010AA302B08）
