重庆医学2013，Vol.42Issue(10)：1132-1133,2.DOI:10.3969/j.issn.1671-8348.2013.10.019
子宫内膜癌中抑癌基因P27蛋白与癌基因P185蛋白的表达及临床意义
Protein expression and clinical significance of tumor suppressor gene P27 and oncogene P185 in endometrial carcinoma
钱沁佳1
作者信息
- 1. 海南省第三人民医院妇产科,海南三亚570000
- 折叠
摘要
Abstract
Objective To discuss the value of combined mark of tumor suppressor gene P27 and oncogene P185 in the early diagnosis of endometrial carcinoma. Methods A total of 66 patients with endometrial carcinoma (carcinoma group) and 29 cases of en-dometrial atypical hyperplasia (hyperplasia group) admitted to our hospital from January 2008 to March 2010,together with 31 patients with normal endometrium (control group) were selected and received S-P immunohistochemistry testing. Results P27 expression has the lowest positive rate in carcinoma group. The differences between groups were statistically significant (P<0. 05), while there was no statistical difference between control group and hyperplasia group (P>0. 05). There is significant difference of P185 expression between carcinoma group and hyperplasia group (P<0. 05). There were significant difference among control group,carcinoma group and hyperplasia group(P<0. 01). Conclusion This study shows that the expression of P27 and P185 protein in endometrial carcinoma has negative correlation. P27 and P1 85 protein plays an important role in the occurrence and regulation of tumor. Clinical combined testing has positive significance in the early diagnosis,treatment and prognosis of tumor.关键词
子宫内膜肿瘤/P27/P185/早期诊断/S-P免疫组化Key words
endometrial neoplasms/P27/P185/early diagnosis/S-P immunohistochemistry引用本文复制引用
钱沁佳..子宫内膜癌中抑癌基因P27蛋白与癌基因P185蛋白的表达及临床意义[J].重庆医学,2013,42(10):1132-1133,2.
