摘要
Abstract
Objective To evaluate the effects of rosuvastatin(ROS) on expression of Periostin protein in rats with acute myocar-dial infarction and to investigate the improvement of myocardial reconstruction mechanism. Methods Thirty female SD rats with li-gated LAD were used to establish models of acute myocardial infarction(AMI) , twenty four hours later, the models were randomly divided into acute myocardial infarction(AMI) as control group(n=15) and ROS group(n= 15) ; Another 15 rats were tested with pierced but not ligated LAD(n=15) as sham-operated group(Sham group). Rats in ROS group were given ROS by gavage at 10 mg/kg dose levels to soluble in 2 ml, clear water, whereas rats in the other two groups were given 2 ml, clear water each day. Four weeks later,compare the differences of collagen volume fraction(CVF) ,Pcriostin protein,TGF-β1 mRNA and Pcriostin mRNA. Results Myocardial CVF,Pcriostin protein,TGF-β1 mRNA and Pcriostin mRNA were reduced in the ROS group compared with rats in the AMI group(P<0. 05) ,both ROS group and AMI group were significantly higher than those in the Sham group(P<0. 05). Conclusion ROS can reduce the expression of Pcriostin in the damaged myocardial,may be one of the mechanism of myocardial remodeling improvement.关键词
心肌梗死/大鼠/瑞舒伐他汀/PeriostinKey words
myocardial infarction/ rats/ rosuvastatin/ Pcriostin
