重庆医学2013，Vol.42Issue(11)：1252-1253,2.DOI:10.3969/j.issn.1671-8348.2013.11.021
螺内酯联合缬沙坦在早期糖尿病肾病治疗中的作用
Application of spironolactone combined with valsartan in the treatment of early diabetic nephropathy
摘要
Abstract
Objective To study the effect of spironoiactonc combined with vaisartan on the renal function of the patients with early diabetic ncphropathy. Methods Fifty-six patients with early diabetic ncphropathy(urinary albumin excretion rate was 30 — < 300 mg/d) were randomly divided into treatment group and control group, with 28 cases in each group. Control group orally took valsartan on the basis of the conventional treatment of diabetes. Spironolactonc was added to treatment group on the basis of the treatment of control group. Both groups were treated for 3 months. 24 h urine albumin and scrum crcatininc level before and after the treatment were compared and analyzed between the two groups. Results 24 h urinary albumin before and after the treatment were significantly different between the two groups(P＞O. 05). 24 h urine albumin and scrum crcatininc level in treatment group were significantly lower than control group after treatment,and the difference showed a statistical significance(P>0. 05). Conclusion Spironolactonc combined with valsartan can reduce urinary protein in patients with early diabetic ncphropathy and protect renal function of the patients with diabetic ncphropathy.关键词
糖尿病肾病/螺内酯/缬沙坦Key words
diabetic ncphropathics/spironolactonc/ valsartan引用本文复制引用
柯箫韵,喻格书,袁慧中,柯佳明..螺内酯联合缬沙坦在早期糖尿病肾病治疗中的作用[J].重庆医学,2013,42(11):1252-1253,2.
