儿科药学杂志2013，Vol.19Issue(3)：35-38,4.
我院抗菌药物临床应用与细菌耐药情况分析
Analysis of Clinical Use of Antibacterials and Antibiotic Resistance in Our Hospital
摘要
Abstract
Objective; To understand the use of antibacterials and antibiotic resistance in our hospital, and to provide reference for clinical rational drug use. Methods; The use of antibacterial drugs in our hospital was analyzed by defined daily dose(DDD) method through 2011 antibacterial drug sales data. The antibiotic resistance rate of pathogenic bacteria was analyzed through bacterial resistance surveillance data. Results: The use of third-generation cephalosporins was the most frequent. In 2011, the main isolated pathogens were Escherichia coli, Staphylococcus aureus, Staphylococcus aureus and Klebsiella pneumoniae. And the most of detection were Escherichia
coli. Producing ESBLs ( extended-spectrum β-lactamases) of Escherichia coli and producing ESBLs of Klebsiella pneumoniae were 100% resistant to third-generation cephalosporins. There was one case that producing ESBLs of Klebsiella pneumoniae was resistant to imipenem. Conclusions; In this hospital third-generation cephalosporins were not reasonable used, and the situation of antibiotic resistance was serious. Irrational use of third-generation cephalosporin is the main factor that causes extended-spectrum (3-lactamases enzyme strains appeared and spread. This problem should be drawn great attention. 关键词
抗菌药物/用药频度/耐药性Key words
Antibacterial drugs/ DDDs/ Drug resistance分类
医药卫生引用本文复制引用
张功武,钱惠..我院抗菌药物临床应用与细菌耐药情况分析[J].儿科药学杂志,2013,19(3):35-38,4.
