广东牙病防治2013，Vol.21Issue(2)：72-74,3.
慢性牙周炎合并冠心病患者牙周基础治疗对细胞因子水平的影响
Influence of periodontal initial therapy on cytokines in patients with chronic periodontitis and coexistent coronary heart disease
摘要
Abstract
Objective To evaluate the influence of periodontal initial therapy on serum cytokines and C-reactive protein (CRP) in patients with severe chronic periodontitis and coexistent coronary heart disease. Methods Thirty-two patients suffered from severe chronic periodontitis and stable coronary heart disease were involved in the study. Peripheral vein blood samples were taken before and four weeks after periodontal initial therapy. Cytokines and CRP levels of serum were measured by radioimmunoassay and immunoturbidimetry respectively. Results Four weeks after periodontal initial therapy, the mean PD (probing depth) of patients decreased from (5.35 ±0.97) mm to (2.72 ±0.65) mm, the mean AL (attachment loss) from (5.83 ± 1. 12) mm to (3.24 ±0.79) mm and the mean BI (bleeding index) from (3.45 ± 0. 83 ) to ( 0. 80 ± 0. 77 ) . And the differences above were all statistically significant ( P ＜ 0. 05 ). The mean levels of serum IL-1β, IL-2 and IL-6 declined, while TNF- α and CRP increased. The decrease of serum IL-1β [from (0. 184 ± 0.045) ng/mL to (0. 145 ± 0. 039) ng/mL ] and the increase of serum TNF- α [ from (1. 082 ± 0. 206) ng/mL to (1. 182 ±0.154) ng/mL] were statistically different (P ＜0. 05). Conclusion Periodontal initial therapy is effective clinically for severe chronic periodontitis patients with coexistent stable coronary heart disease. It could also reduce the level of serum IL-1β and increase the level of serum TNF- α.关键词
慢性牙周炎/冠心病/细胞因子/C反应蛋白Key words
Chronic periodontitis/ Coronary heart disease/ Cytokines/ C-reactive protein分类
医药卫生引用本文复制引用
于江波,张月,杨芳,张春艳,郭大伟,张广耘..慢性牙周炎合并冠心病患者牙周基础治疗对细胞因子水平的影响[J].广东牙病防治,2013,21(2):72-74,3.基金项目
青岛市医药科研指导计划(2010-WSZD009) （2010-WSZD009）
