广东医学2013，Vol.34Issue(6)：835-837,3.
阿托伐他汀对脑外伤大鼠内皮祖细胞和空间认知及记忆功能的影响
Atorvastatin regulates endothelial progenitor cells and improves spatial cognition and memory function in rats with traumatic brain injury.
摘要
Abstract
Objective To evaluate the effects of atorvastatin on endothelial progenitor cells( EPCs ), and the spatial cognition and memory function in rats with traumatic brain injury ( TBI ). Methods Thirty - six adult male Wistar rats were randomly divided into sham group, treatment group and control group. Hydraulic combat was adopted to produce TBI in the treatment group and the control group, while sham surgical procedure without percussion injury was adopted in the sham group. Atorvastatin ( orally, 1 mg/kg ) treatment was given to the subjects in treatment group. Circulating EPCs were measured 7, 14 and 21 d after TBI. The mNss test was conducted 1,4,7, 14 and 21 d after TBI. The MWM during 21 ~25 d after TBI were also conducted, with the percentage of target quadrant recorded. Results Hydraulic combat impaired spatial cognition and memory function in rats. The EPC count was significant differed between the treatment group and the control group ( P <0. 05 ). The escape latencies were significantly higher in treatment group than that in control group on day 24 and day 25. Conclusion Atorvastatin can regulate circulating EPCs, improve spatial cognition and memory function in rats with TBI.关键词
阿托伐他汀/颅脑损伤/内皮祖细胞/大鼠/空间认知Key words
atorvastatin/ traumatic brain injury/ endothelial progenitor cell/ rats/ spatial cognition引用本文复制引用
金卫篷,王彬,赵子龙,尉辉杰,张永强,张建宁..阿托伐他汀对脑外伤大鼠内皮祖细胞和空间认知及记忆功能的影响[J].广东医学,2013,34(6):835-837,3.基金项目
国家自然科学基金资助项目(编号:81271361,81200907),天津市卫生局科技基金资助项目(编号:2012KZ086) （编号:81271361,81200907）
