广东药学院学报2013，Vol.29Issue(1)：25-28,4.DOI:10.3969/j.issn.1006-8783.2013.01.006
3-取代喹喔啉衍生物的合成及其抗肿瘤活性的研究
Study on synthesis and antitumour activities of 3-subsitituted quinoxaline derivatives
摘要
Abstract
Objective To synthetize 3-substituted quinoxaline derivatives and study their anti-tumor activities on cell K562 and PANC-1. Methods The compounds were synthesized with the reaction of 1,2-diaminobenzene and 1 ,2-dione compounds diethyl oxalate by cyclization, chloro and nucleophilic substitution. MTT method was used to evaluate antitumor activities of their compounds. Results Seven new compounds were synthesized and characterized by IR and 1H-NMR. The inhibition ratio of Compound 6 on K562 cell was the best with IC50 0.836 μmol · L-1. Conclusion Seven new 3-substituted quinoxaline derivatives were synthesized and had good antitumor activity in vitro.关键词
喹喔啉/衍生物/合成/抗肿瘤活性Key words
quinoxaline/ synthesis/ antitumor activity分类
医药卫生引用本文复制引用
张春玲,许秀枝,王艰,杨州,李柱来..3-取代喹喔啉衍生物的合成及其抗肿瘤活性的研究[J].广东药学院学报,2013,29(1):25-28,4.基金项目
福建省教育厅科技项目(JA11115) （JA11115）
福建医科大学教授基金(JS10005) （JS10005）
