广东药学院学报2013，Vol.29Issue(1)：64-68,5.DOI:10.3969/j.issn.1006-8783.2013.01.015
舒洛地特对慢性环孢素肾病大鼠的保护作用
Effect of sulodexide on the chronic cyclosporine nephropathy in rats
摘要
Abstract
Objective To observe the effect of sulodexide on the chronic cyclosporine nephropathy (CCN) in rats. Methods Wistar rats were randomly divided into 6 groups, including the normal control group, the model group,benazepril group,and three sulodexide groups with different dosages. Rats body weight was checked,and blood was collected to measure the levels of blood urea nitrogen (BUN) and serum creatinine (Scr). Kidney tissues were collected and stained with HE, PAS and maxson. Pathological changes, hyaline degeneration of small arteries and renal interstitial fibrosis were assessed. The ultrastructural changes of kidney tissues were also observed by electron microscopy. Results After CsA administration, the weight of rats decreased and the levels of serum BUN and Scr elevated in the model group, but which was arrested in benazepril group and all sulodexide groups. Compared with the normal control group,CCN was found in the kidney tissues in the model group,but CCN was inhibited when treated with benazepril or sulodexide. Compared with the normal control group, thickened glomerular and tubular basement membrane, pyknosis, and increased collagen fiber in interstitium were found in the model group, but these pathological changes were lightened when treated with benazepril or sulodexide. Conclusion Sulodexide treatment could significantly reduce chronic cyclosporine nephropathy,and the effect is better than benazepril.关键词
舒洛地特/慢性环孢素肾病/肾间质纤维化Key words
sulodexide/ chronic cyclosporine nephropathy/ renal interstitial fibrosis分类
医药卫生引用本文复制引用
王妍春,胡卫列,童俊容,王淑美,王寅,唐咸国..舒洛地特对慢性环孢素肾病大鼠的保护作用[J].广东药学院学报,2013,29(1):64-68,5.基金项目
广东省科技项目攻关课题(2069999) （2069999）
