神经损伤与功能重建2013，Vol.8Issue(2)：88-92,5.DOI:10.3870/sjsscj.2013.02.003
阿尔茨海默病APPswe/PS1dE9双转基因小鼠的行为学研究
Behavioral Assessment of APPswe/PS1dE9 Double Transgenic Mice of Alzheimer's Disease
摘要
Abstract
Objective: To investigate the sensorimotor activity/locomotor activity, emotion disorders and the object-recognition capability of APPswe/PS1dE9 double transgenic (Tg) mice. Methods: Open field test (OFT) and novel object recognition test (NORT) were performed in APPswe/PS ldE9 double transgenic mice and their age- and gender-matched wild type (wt) littermates at 6 months (female, male) and 12 months (male) of age respectively. Results: Compared to their controls, only 12 month-old Tg mice showed hypoactivity and increased anxiety profile in the OFT (P<0.05). No significant differences between the Tg and wt mice had been detected in the NORT. Conclusion: APPswe/PSldE9 double Tg mice can preferably recapitulate some behavioral and psychological phenotypes of AD patients, and hence provide a valuable tool to explore the pathogenesis and effective therapeutic strategies of AD.关键词
阿尔茨海默病/APPswe/PS1dE9/旷场实验/新颖物体识别Key words
Alzheimer's disease/APPswe/PS1dE9/open field test/novel object recognition分类
医药卫生引用本文复制引用
陈妍林,李志军,张旻..阿尔茨海默病APPswe/PS1dE9双转基因小鼠的行为学研究[J].神经损伤与功能重建,2013,8(2):88-92,5.基金项目
国家自然科学基金(No.81271406,No.81000537)教育部新世纪优秀人才资助项目(No.NCET-09-0394) （No.81271406,No.81000537）
