广西医学2013，Vol.35Issue(2)：138-141,4.DOI:10.11675/j.issn.0253-4304.2013.02.04
软坚护肝片的急性毒性及一般药理学研究
Study on Acute Toxicity and General Pharmacology of Ruanjian Hugan Tablet
摘要
Abstract
Objective To study the acute toxicity of Ruanjian Hugan Tablet in the experimental animals and its influence on the central nervous system, cardiovascular system and respiratory system of the animals. Methods Twenty mice were given Ruanjian Hugan Tablet( 19. 84 g/kg ) according to the method of maximum administration dosage for 14 days,twice per day,then the acute toxicity reaction of the mice was observed;Different dosages of Ruanjian Hugan Tablet( 0.31,0. 62,1. 24 g/kg ) were given to the mice in each group by gavage for observation of the mice's spontaneous activity and coordinating ability of movement; Different dosages of Ruanjian Hugan Tablet( 0. 31,0. 62, 1.24 g/kg ) were given to the anesthetic rats in each group via duodenum to observe diastolic pressure( DP ), systolic pressure( SP ), mean artery pressure( MAP ), heart rate ( HR ), respiratory rate and range of the rats. Results After being administrated with Ruanjian Hugan Tablet( 19. 84 g/kg ) by gavage for 14 days, the mice showed no toxicity reaction. Different dosages of Ruanjian Hugan Tablet had no significant effect on the spontaneous activity and coordinating ability of movement in mice( P >0.05 ),and had no significant effect on blood pressure,MAP,HR,respiratory rate and range in anesthetic rats( P >0.05 ). Conclusion Ruanjian Hugan Tablet showed no significant effect on the cardiovascular system, respiratory system, and central nervous system of experimental animals.关键词
软坚护肝片/急性毒性试验/药理学/中枢神经系统/心血管系统/呼吸系统Key words
Ruanjian Hugan Tablet/Acute toxicity test/Pharmacology/Central nervous system/Cardiovascular system/Respiratory system分类
医药卫生引用本文复制引用
汪永玲,孔晓龙,莫凤珍,梁凯,覃振明..软坚护肝片的急性毒性及一般药理学研究[J].广西医学,2013,35(2):138-141,4.基金项目
广西科学研究与技术开发计划项目(10124008-7) （10124008-7）
