广西医学2013，Vol.35Issue(3)：282-285,4.DOI:10.11675/j.issn.0253-4304.2013.03.08
颅脑损伤急性期C-反应蛋白与脑损伤程度、病情发展及预后的关系探讨
Correlation of C-Reactive Protein with Severity, Progression and Prognosis of Brain Injury in Acute Stage
摘要
Abstract
Objective To explore the correlation of C-reactive protein( CRP ) in cerebrospinal fluid and serum with severity, progression and prognosis of brain injury in acute stage. Methods According to glasgow coma score ( GCS ),65 patients with brain injury were divided into three groups, 15 patients in mild group,20 patients in moderate group ,30 patients in sever group. The cerebrospinal fluid and serum were collected from the patients in the period of one day to four weeks after they were hurt. Immunoturbidimetric assay was used to detect the level of CRP in cerebrospinal fluid and serum which was compared with the real-time imaging data. Results There was significant difference in the level of CRP detected 7 days after injury among mild group, moderate group and sever group( P <0.01 );The changes of CRP correlated with imaging changes, and suggested the disease trend. Conclusion The level of CRP in cerebrospinal fluid and serum is a sensitive index to reflect brain injury in acute stage,which is of great value for judging the disease's progression, efficacy and prognosis.关键词
颅脑损伤/C-反应蛋白/影像学/病情变化/预后Key words
Brain injury/C-reactive protein/Imaging/Disease trend/Prognosis分类
医药卫生引用本文复制引用
周志宇,农朝赞,谢昌纪,韦成聪,蓝欢,黄纯真..颅脑损伤急性期C-反应蛋白与脑损伤程度、病情发展及预后的关系探讨[J].广西医学,2013,35(3):282-285,4.基金项目
广西自然科学基金(0991199) （0991199）
