广西医学2013，Vol.35Issue(3)：292-297,6.DOI:10.11675/j.issn.0253-4304.2013.03.11
心内直视术后早期认知功能障碍危险因素的logistic回归分析
Logistic Regression Analysis of Risk Factors of Early Postoperative Cognitive Dysfunction in Patients after Open Heart Surgery
摘要
Abstract
Objective To investigate the risk factors of early postoperative cognitive dysfunction( POCD ) in patients after open heart surgery. Methods A total of 315 patients undergoing open heart surgery were divided into POCD group and non-POCD group by the mini-mental state examination( MMSE ) 7 days before and after operation, respectively. The gender,age,body mass index and other 23 related factors were collected from both groups. The independent risk factors of early POCD after open heart surgery were determined by univariate and multivariate logistic regression analysis. Results Of 301 patients who completed the study ,138( 45.8% ) cases developed POCD. Univariate analysis showed that age,level of education, smoking, drinking, hypertension, coronary heart disease, diabetes, cerebrovascular disease, drug dependence, dosage of atropine, time of cardiopulmonary bypass, time of operation, intra-operative hypotension and postoperative pain were significantly different between two groups( P <0. 05 ). Multivariate logistic regression analysis suggested that age, smoking,drinking,hypertension,diabetes,dosage of atropine,time of cardiopuhnonary bypass and intra-operative hypotension were the independent risk factors associated with early POCD in patients after open heart surgery( all P <0.05 ),level of education was the protective factor. Conclusion POCD is a common complication after open heart surgery. Age,smoking, drinking, hypertension, diabetes, dosage of atropine, time of cardiopulmonary bypass and intra-operative hypotension are the independent risk factors associated with early POCD in patients after open heart surgery, and level of educational is a protective factor of POCD.关键词
心内直视术/认知功能障碍/危险因素/logistic回归分析Key words
Open heart surgery/Cognitive dysfunction/Risk factor/Logistic regression analysis分类
医药卫生引用本文复制引用
涂杰,张炳东,韦秋英,李涛,何芳..心内直视术后早期认知功能障碍危险因素的logistic回归分析[J].广西医学,2013,35(3):292-297,6.基金项目
广西卫生厅科研立项课题(Z2012109) （Z2012109）
