郑州大学学报（医学版）2013，Vol.48Issue(1)：35-38,4.DOI:10.3969/j.issn.1671-6825.2013.01.009
血液透析患者阿司匹林出血事件的meta分析
Aspirin in hemodialysis patients:a meta analysis of bleeding events
摘要
Abstract
Aim: To identify the risk of bleeding in hemodialysis patients with aspirin. Methods : Prospective randomized controlled trails( RCT) of aspirin in the hemodialysis patients were selected from database such as Medline, Cochrane Controlled Trials Register, VIP Database, CNKI, CBM. Quality of Lhe RCTs was evaluated, and the data met the inclusion criteria were extracted. Review Manager Software 4.2 was used for statistical analysis. Results :Ten trials with a total of 686 participants were included. The meta analysis showed bleeding events occurred in 44 patients,20 in aspirin group,24 in control group. There was no significant dilference between the two groups in bleeding events( OR = 0. 90,95% CI = 0. 47 ~ 1. 72,P = 0. 74 ). Otherwise, there were 104 patients with thrombosis events reported in eight trials. The meta analysis showed aspirin significantly reduced the risk of thrombosis events in hemodialysis vascular access( OR = 0. 37 ,95% CI = 0. 16 ~ 0. 84, P =0.02 ). Conclusion : Aspirin may not increase the risk of bleeding in hemodialysis patients, but reduce the risk of thrombosis in vascular access.关键词
阿司匹林/血液透析/出血事件/meta分析Key words
aspirin/hemodialysis/bleeding event/meta analysis分类
医药卫生引用本文复制引用
聂晟,谢迪,李璐,梁敏..血液透析患者阿司匹林出血事件的meta分析[J].郑州大学学报（医学版）,2013,48(1):35-38,4.基金项目
国家自然科学基金面上项目 30971382 （）
