湖南中医药大学学报2013，Vol.33Issue(1)：128-131,4.DOI:10.3969/j.issn.1674-070X.2013.01.035.0128.04
乙型肝炎相关性肝衰竭不同黄疸证的肠道菌群分析
Analysis of the intestinal flora of hepatitis B-related liver failure with different jaundice syndrome
摘要
Abstract
Objective To study the relationship between the intestinal flora characteristics and endotoxemia in different jaundice syndrome of hepatitis B -related liver failure. Methods By stool cultures of 30 patients with hepatitis B-related liver failure (15 cases were yang jaundice and 15 cases were yin-yang jaundice) and 10 healthy persons, the amounts of intestinal flora including enterococci, enteric bacilli, Bacteroides, Bifidobacterium, Lactobacillus were determined. The plasma endotoxin levels of these persons were measured using limulus polyphemus test. Results (1) Compared with those of health group, the amounts of enterococci and enteric bacilli in yang jaundice group were significantly increased (P<0.05 ,P<0.01). (2) Compared with those of health group, the amount of enterococci in yin-yang jaundice group was increased significantly (P<0.01), and the amount of enteric bacilli was increased slightly without statistically significant(P>0.05), Bifidobacterium and Lactobacillus were reduced obviously (P<0.01 and P<0.05). (3) Compared with those of health group, plasma endotoxin levels of hepatitis B-related liver failure were significantly increased (P<0.05 and P<0.01) and yin-yang jaundice group was higher than yang jaundice group. Conclusion In the "yang jaundice-yin-yang jaundice-yin jaundice" process of hepatitis B-related liver failure, the degree of imbalance of intestinal flora is more and more obvious, aerobes are increasing and anaerobes are reducing, plasma endotoxin levels are gradually heightened with the aggravation of the spleen deficiency symptoms. It is a pathophysiological basis of yin jaundice mechanism.关键词
乙型肝炎相关性肝衰竭/黄疸证/肠道菌群/血浆内毒素Key words
Hepatitis B-related liver failure/jaundice/intestinal flora/plasma endotoxin分类
医药卫生引用本文复制引用
朱文芳,孙克伟,陈斌,胡莉,王轩..乙型肝炎相关性肝衰竭不同黄疸证的肠道菌群分析[J].湖南中医药大学学报,2013,33(1):128-131,4.基金项目
湖南省中医药科研计划项目(201137) （201137）
湖南中医药大学青年教师科研基金项目(201039). （201039）
