华中师范大学学报（自然科学版）2013，Vol.47Issue(2)：200-203,253,5.
2-取代苯甲酰氨基-5-苯甲叉基-4-噻唑酮衍生物的合成与生物活性研究
Synthesis and bioactivity of 2-acylamino-5-benzylidenethiazol-4-ones
摘要
Abstract
A series of new 2-acylamino-5-benzylidenethiazol-4-ones (4) have been designed and synthesized by the reactions of substituted benzoyl chloride with intermediate 3. The structures of compounds 4 were characterized by IR, 1H NMR, 13C NMR and elemental analysis. The results of bioassay indicate that some compounds possess a certain antitumor activity against KB and CNE2, and the title compound 4a showed certain fungicidal activity against six tested fungi.关键词
噻唑酮衍生物/抗肿瘤活性/杀菌活性Key words
thiazolone/ antitumor activity/ fungicidal activity分类
化学化工引用本文复制引用
刘勇军,吕冬娥,高玉焦,彭浩,贺红武..2-取代苯甲酰氨基-5-苯甲叉基-4-噻唑酮衍生物的合成与生物活性研究[J].华中师范大学学报（自然科学版）,2013,47(2):200-203,253,5.基金项目
国家重点基础研究发展规划项目973计划(2010CB126100) （2010CB126100）
国家自然科学基金项目(21172090). （21172090）
