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TRPM家族对细胞钙/镁平衡调控的研究进展

张厉 杨春喜 贺石生

基础医学与临床2013,Vol.33Issue(3):370-373,4.
基础医学与临床2013,Vol.33Issue(3):370-373,4.

TRPM家族对细胞钙/镁平衡调控的研究进展

Recent advances in the study of regulation effect of TRPM family in cellular calcium/magnesium homeostasis

张厉 1杨春喜 2贺石生1

作者信息

  • 1. 上海市第十人民医院同济大学附属第十人民医院骨科,上海200072
  • 2. 南京医科大学第一临床医学院,江苏南京210029
  • 折叠

摘要

Abstract

Melastatin-related transient receptor potential (TRPM) channels are members of the transient receptor potential (TRP) channel superfamily. All the members are permeable to Ca2+ and Mg2+ except TRPM4 and TR-PM5. TRPM1, TRPM2, TRPM3 and TRPM8 are regulators of Ca2+ and magnesium homeostasis, TRPM6 and TRPM7 are key regulators of Mg2+ homeostasis. TRPM channels are widely distributed and activated by a variety of stionulation. They play a fundmental role in regulating cellular calcium / magnesium homeostasis and other various cell biological processes.

关键词

TRPM阳离子通道/钙离子平衡/镁离子平衡

Key words

TRPM cation channels/ calcium homeostasis/ magnesium homeostasis

分类

医药卫生

引用本文复制引用

张厉,杨春喜,贺石生..TRPM家族对细胞钙/镁平衡调控的研究进展[J].基础医学与临床,2013,33(3):370-373,4.

基金项目

国家自然科学基金(81101344/H0604) (81101344/H0604)

同济大学附属第十人民医院优秀青年人才培养计划(11RQ104) (11RQ104)

基础医学与临床

OA北大核心CSCDCSTPCD

1001-6325

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