张燕 1张素华 1龚莉琳 1任伟 1汲宝兰 1段凤仪 1桂灵升 1李蓉1
作者信息
摘要
Abstract
Objective To investigate the correlation between lipid accumulation product (LAP), visceral adiposity index (VAI) and high-sensitivity C-reactive protein (hs-CRP) in adults, and explore whether to use such correlation as indications is superior to the traditional body fat index based on body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR). Methods The present work was a cross-sectional study involving 501 healthy adults (321 males and 180 females) from the community of Chongqing Municipality. Anthropometric indexes [height, weight, WC, hip circumference (HC)], blood pressure (BP), fasting lipid profile and levels of fasting and post-load glucose, insulin and hs-CRP were measured, and BMI, WHR, WHtR, fasting insulin resistant homeostasis model assessment (HOMA-IR), LAP and VAI were calculated. The correlations between hs-CRP and other variables were analyzed. Results Following the elevation of titer of the hs-CRP, LAP, VAI, BMI, WC, WHR, WHtR, BP, glucose level, HOMA-IR, insulin, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) increased (P<0.05), while high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A, (ApoA1) levels declined (P<0.000l). Pearson's correlation analysis demonstrated that hs-CRP was correlated with all variances (P<0.0) except for total cholesterol (TC) (P=0.18l) and LDL-C (P=0.325). According to forward stepwise multiple regression analysis with hs-CRP as the dependent variance, WC was the only variance entering the regression model. Conclusion LAP, VAI levels are correlated with hs-CRP level but not the major determinant factors of hs-CRP. WC is stronger than other variances in the association with hs-CRP in adults, and is still an independent predictor of inflammation.关键词
C反应蛋白质/脂质蓄积指数/内脏脂肪指数Key words
C-reactive protein/ lipid accumulation product/ visceral adiposity index分类
医药卫生
