昆明医科大学学报2013，Vol.34Issue(1)：47-52,6.
血管紧张素-(1-7)对野百合碱诱导的肺动脉高压及右心室重构的影响
Effects of Ang-(1-7) on Pulmonary Hypertension and Right Ventricular Remodeling in Monocrotaline-Treated Rats
摘要
Abstract
Objective To investigate the therapeutic effects of Ang- (1-7) on pulmonary hypertension and right ventricular remodeling in monocrotaline-treated rats. Methods Thirty SD rats were randomly divided into three groups: control group, MCT group and Ang- (1-7) group. Rats in MCT group and Ang- (1-7) group received 60mg/kg MCT injection subcutaneously and after 24 hours received either saline or 24ug/kg/h of Ang-( 1-7) injection via osmotic minipumps for four weeks. The rats in control group were firstly injected saline subcutaneously and then received saline injection via osmotic minipumps for four weeks. Right ventricular free wall thickness (RVFWT) , pulmonary arterial acceleration time (PAAT) and tricuspid regurgitation were measured by echocardiography. Right ventricular systolic pressure (RVSP) , mean arterial pressure (MAP) and heart rate (HR) were measured. The animals' hearts were measured to calculate the ratio of right ventricle to left ventricle plus septum (RVHI=RV/LV+S) and right ventricle mass to body weight (RVMI=RV/BW) . Histopathological changes of lung and right ventricle were observed by hematoxylin and eosin staining. Percentage of wall thickness (WT%) and percentage of wall area ( WA% ) of pulmonary arterioles were evaluated. RestultS Four weeks after monocrotaline injection, compared with control group, RVSP, RVHI, RVMI, WT%, WA % and RVFWT were significantly increased in MCT group, PAAT were significantly decreased in MCT group. Some rats occured tricuspid regurgitation and right ventricle occured cardiomyocyte hypertrophy in MCT group. However, no significant difference was found between Ang- (1-7) group and control group among the above parameters. Conclusion Ang- (1-7) may inhibit pulmonary arterial hypertension and right ventricular remodeling in monocrotaline-treated rats.关键词
血管紧张素-(1-7)/野百合碱/肺动脉高压/重构Key words
Ang- (1 -7) / Monocrotaline/ Pulmonary arterial hypertension/ Remodeling分类
医药卫生引用本文复制引用
陈丽星,孙金华,胡钊,肖践明,郭涛,赵玲,韩明华..血管紧张素-(1-7)对野百合碱诱导的肺动脉高压及右心室重构的影响[J].昆明医科大学学报,2013,34(1):47-52,6.基金项目
云南省教育厅科学研究基金资助项目(2010Y173) （2010Y173）
