昆明医科大学学报2013，Vol.34Issue(2)：71-74,4.
先心病心脏重构患者血清血管紧张素转化酶2水平研究
The Serum Levels of Angiotensin-converting Enzyme2 in Patients of Congenital Heart Disease with Cardiac Remodeling
摘要
Abstract
Objective To observe the Angiotensin-converting enzyme2 (ACE2) protein contents and activity in the serum of patients with Congenital Heart Disease (CHD) combined with cardiac remodeling (CR) , and investigate the correlation of those with cardiac remodeling. Methods 104 patients with Congenital Heart Disease and 33 normal control patients were collected. The patients with congenital heart disease were divided into 80 cases of non-cardiac remodeling group, and 24 cases of cardiac remodeling group. The serum levels of ACE2 protein were detected by enzyme-linked immunosorbent assay ( ELISA) , ACE2 activity was detected by colorimetric method. Statistical analysis was performed by using SPSS software. Results (1) The ACE2 protein contents in serum measured by enzyme-linked immunosorbent assay were (15.79 ± 5.03) U/L, (18.85 ± 6.46) U /L, (14.80 ± 4.58) U/L in normal control group, Congenital Heart Disease with non-cardiac remodeling group, Congenital Heart Disease with cardiac remodeling group.The levels of ACE2 protein showed significant difference between normal control group and Congenital Heart Disease with non-cardiac remodeling group (P<0.05). The levels of ACE2 protein showed no significant difference between normal control group and Congenital Heart Disease with cardiac remodeling group (P>0.05). The levels of ACE2 protein showed significant difference between Congenital Heart Disease with non-cardiac remodeling group and Congenital Heart Disease with cardiac remodeling group (P<0.01). (2) The ACE2 activities in plasma measured by activity colorimetric were (1.75 ±0.82) U/L, (1.85 ±0.62) U/L, (1.58 ±0.52) U/L in normal control group, Congenital Heart Disease with non-cardiac remodeling group, and Congenital Heart Disease with cardiac remodeling group. There were no significant differences among three groups (P>0.05). Conclusions ( 1) ACE2 protein contents in the patients with Congenital Heart Disease combined with non-cardiac remodeling have significantly increased. (2) ACE2 activity has no differences in the patients with Congenital Heart Disease combined with non-cardiac remodeling and Congenital Heart Disease combined with cardiac remodeling.关键词
心脏缺损/先天性/心脏重塑/血管紧张素转化酶2Key words
Heart defects/ Congenital/ Cardiac remodeling/ Angiotensin-converting enzyme2分类
医药卫生引用本文复制引用
郭玥,吕宁,尹小龙..先心病心脏重构患者血清血管紧张素转化酶2水平研究[J].昆明医科大学学报,2013,34(2):71-74,4.基金项目
云南省自然科学基金资助项目(2012FB009) （2012FB009）
