兰州大学学报（医学版）2012，Vol.38Issue(3)：52-55,4.
小潮气量机械通气对全麻患儿术中肺功能的影响
Influence of small tidal volume mechanical ventilation to lung function of children in general anesthesia
摘要
Abstract
Objective To study the effect of low tidal volume mechanical ventilation on the lung protection of children in intraoperative anesthesia. Methods 48 cases of children with intestinal obstruction laparotomy were selected and randomly divided into A and B groups. The two groups were treated with low tidal volume and high tidal volume mechanical ventilation separately. Their peripheral blood were collected before intubation, after intubation 1 h and at the end of surgery, using enzyme-linked immunosorbent assay (ELISA) to test patients' plasma interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentration and to analyze arterial blood gas at the same time. Results The two groups in plasma IL-6 levels in tracheal intubation had no significant difference before. In group A there was no significant difference in IL-6 levels. Group B's plasma levels of IL-6 1 h after intubation and at the end of surgery was significantly higher (P <0.05) compared with before intubation. Two groups' plasma levels of TNF-α before intubation had no significant difference and group B's levels were significantly higher (P <0.05) than those 1 h after intubation and at the end of surgery compared with before intubation. Conclusion Tidal volume ventilation can cause increase of plasma IL-6 and TNF-α level in children, which may be one of the reasons to result in mechanical ventilation-induced lung injury. The low tidal volume ventilation used for children in the maintenance of anesthesia in ventilation can contribute to the protection of lung function.关键词
小潮气量/机械通气/全麻/肺功能Key words
low tidal volume/ ventilation/ general anesthesia/ lung function分类
医药卫生引用本文复制引用
李体忠,刘亚玲,罗炜,马源..小潮气量机械通气对全麻患儿术中肺功能的影响[J].兰州大学学报（医学版）,2012,38(3):52-55,4.
