兰州大学学报（医学版）2013，Vol.39Issue(1)：23-26,4.
自旋标记查耳酮类化合物的合成及抗肿瘤活性
Synthesis and biological evaluation of spin-labelled derivatives of chalcones
摘要
Abstract
Objective To find new spin labelled chalcones as anti-tumor drugs with potent activities and low toxicities. Methods A series spin labelled chalcones were synthesized by condensation reaction of aromatic aldehyde and acetpophenone, following acetylation. The cytotoxic activities against six tumor cell lines (P388, A-549, HT-29, MDA-MB-231, SGC-7901, BEL-7402) in vitro of synthetic compounds were also evaluated by MTT method. Results Compounds 3a and 3c showed more than 60% proliferation inhibitions against all six tested tumor cell lines in vitro. Conclusion The amides of spin-labelled chalcones present better anti-tumor activities in vitro.关键词
查耳酮/自旋标记/抗肿瘤活性Key words
chalcone/ spin labelled/ antitumor activity分类
化学化工引用本文复制引用
金岩,刘杰,陈世武..自旋标记查耳酮类化合物的合成及抗肿瘤活性[J].兰州大学学报（医学版）,2013,39(1):23-26,4.基金项目
青岛科技大学引进人才科研启动基金(QUST 0022380) （QUST 0022380）
