临床肝胆病杂志2013，Vol.29Issue(2)：114-116,119,4.
干扰素联合核苷(酸)类似物治疗慢性乙型肝炎的疗效观察
Therapeutic efficacy of combination therapy with interferon and a nucleoside analogue for treating chronic hepatitis B patients
何艳 1唐晓鹏 1郑宣鹤 1姚运海 1张权 1张永红 1陈军1
作者信息
- 1. 中南大学湘雅二医院感染科,长沙410011
- 折叠
摘要
Abstract
Objective To observe the therapeutic efficacy of combination therapy with interferon (IFN ) and a nucleoside analogue for treating chronic hepatitis B ( CHB ) patients. Methods Two - hundred - and - seven patients diagnosed with CHB were assigned to the following treatment groups: IFN in combination with a nucleoside analogue ( group A) ; IFN monotherapy (group B). The patients in group A were further divided into three combination treatment sub - groups, according to the particular nucleoside analogue administered: lamivudine ( LAM; sub - group Al, n = 59 ) ; adefovir dipivoxil ( ADV; sub - group A2, n = 56 ) ; and entecavir ( ETV; sub - group A3 ; n = 31) . All of the patients received pegylated - IFN ( either IFN - 2a or IFN - 2b) for 52 weeks. The patients in group A received the combination therapy with nucleoside analogue immediately upon initiation of the IFN treatment and lasting for a total of 24 weeks, after which IFN mono-therapy was carried out. Results In groups A and B, respectively, 86. 3% and 65.6% achieved undetectable levels of HBV DNA at the end of treatment. However, group A achieved a higher rate of alanine aminotransferase (ALT) normalization rate (87.7% vs. group B; 76.5% , P<0.05). Group A also achieved a significantly higher rates of hepatitis B e antigen (HBeAg) clearance (69.3% vs. group B: 40% , P<0.05) , hepatitis B surface antigen (HBsAg) clearance (30. 1% vs. group B; 16.4% , P<0.05) , and HBsAg seroconversion (26.7% vs. group B; 11.5% , P<0.05). Conclusion The combination treatment of IFN plus a nucleoside analogue is more efficacious than IFN monotherapy for treating CHB patients. 关键词
肝炎,乙型,慢性/干扰素类/核酸类,核苷酸类和核苷类Key words
hepatitis B, chronic/ interferons nucleic acids/ nudeotides, and nucleoside分类
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何艳,唐晓鹏,郑宣鹤,姚运海,张权,张永红,陈军..干扰素联合核苷(酸)类似物治疗慢性乙型肝炎的疗效观察[J].临床肝胆病杂志,2013,29(2):114-116,119,4.
